# GHK-Cu for dogs: dosage chart by weight

GHK-Cu dosage for dogs by weight band, in pen units and micrograms: how long a cartridge lasts, the vial conversion and the research. Canitide COAT.

Canonical: https://canitide.com/dosing/ghk-cu-for-dogs/
Updated: 2026-10-13

GHK-Cu is a copper-binding tripeptide studied for collagen production, skin remodeling and wound support. It is one of the few peptides with genuine canine research: open-wound healing work in dogs in the 1990s.

Owners use it for dull coats, senior skin and dogs prone to hot spots. Canitide COAT is 50 mg of GHK-Cu in one pre-mixed cartridge, dosed daily for eight weeks.

Printable chart (PDF): https://canitide.com/assets/downloads/ghk-cu-for-dogs-dosage-chart.pdf

## GHK-Cu dose by weight band (Canitide COAT, Daily · 8-week cycle, then maintenance)

| Weight band | Per dose | Per dose (mcg) | Per week | Cartridge lasts | Club cadence |
|---|---|---|---|---|---|
| Small (under 20 lb) | 4 units | 668 mcg | 28 units | ~10 weeks | every 8 weeks |
| Medium (20–50 lb) | 6 units | 1002 mcg | 42 units | ~7 weeks | every 6 weeks |
| Large (50–90 lb) | 8 units | 1336 mcg | 56 units | ~5 weeks | every 4 weeks |
| Giant (90 lb and up) | 10 units | 1670 mcg | 70 units | ~4 weeks | every 4 weeks |

## If you use a vial

A 50 mg vial of GHK-Cu in 3 mL of bacteriostatic water is 16.7 mg/mL, the same concentration as a COAT cartridge. On a U-100 insulin syringe one unit is also 0.01 mL.

## Questions

### What is the GHK-Cu dose for dogs?

COAT doses 4, 6, 8 or 10 units a day by weight band (under 20 lb, 20–50 lb, 50–90 lb, 90 lb and up). One unit of COAT carries about 167 mcg of GHK-Cu.

### Is GHK-Cu safe for dogs?

GHK-Cu has canine wound-healing research and a long record of topical use in people, but no controlled canine trial of injectable use. The usual cautions apply: talk to your vet, watch the injection site, stop if anything worries you.

### Can I use GHK-Cu on the skin instead?

A topical COAT Serum is on the Canitide roadmap for summer 2027. Today COAT is a cartridge for the pen.

### How long until the coat changes?

Owners typically report changes over the eight-week cycle, not in the first days. Track it with photos in Fieldnotes so you and your vet can see it rather than remember it.

## The research

- Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Pickart L, Margolina A Int J Mol Sci 2018 (review)
- Evaluation of multipeptide copper complex medications on open wound healing in dogs. Swaim SF et al. J Am Anim Hosp Assoc 1993 (dogs)
- The human tri-peptide GHK and tissue remodeling. Pickart L J Biomater Sci Polym Ed 2008 (review)