# BPC-157 and TB-500: the research behind REPAIR

A walk through the tendon, ligament and gut studies behind REPAIR, and how the weight bands are built from them.

Canonical: https://canitide.com/journal/bpc-157-tb-500-what-research-shows/
Updated: 2026-10-11

REPAIR pairs two peptides that have been used together for years in working-dog and equine recovery. Here is the research base for each, and how we dose from it.

## BPC-157: three decades of rodent tendon work

The Zagreb group led by Predrag Sikirić has published on the stable gastric pentadecapeptide BPC 157 since the early 1990s. The studies most relevant to dogs are the orthopedic ones. In a 2003 rat model, transected Achilles tendons treated with BPC 157 healed with better function and structure than controls. Cell-culture work in 2011 and 2014 showed the peptide promoted tendon fibroblast outgrowth, survival and migration. A 2022 study measured how the compound is absorbed and cleared in rats and beagle dogs after intravenous and intramuscular dosing.

The gut research is older and broader: BPC 157 was originally investigated for gastric and intestinal protection, which is why an oral form is credible and why it anchors our GUT capsules.

## TB-500: the repair-cell courier

Thymosin beta-4 is a naturally occurring 43-amino-acid protein that sequesters actin and has been shown, in mouse models, to promote cell migration and cardiac repair. The material sold as TB-500 is a shorter synthetic fragment; a 2012 analytical study characterized an acetylated seven-residue fragment in a tested preparation. Full-length thymosin beta-4 research cannot simply be transferred to the fragment.

## Why the pairing

The working theory in the field is that BPC-157 acts locally on blood supply and tendon cells while the thymosin fragment supports repair-cell movement. We pair them the way working-dog vets have for years, and we dose each to your dog's weight so the amounts are known.

## How the weight bands are built

The published mg/kg ranges from the animal studies are scaled to four canine weight bands, rounded to whole pen units, and capped so one cartridge always covers at least a four-week cadence. The result is a number on a card: your dog's units, nothing to convert. The citations for everything above are on the [Science page](/science/), marked with the model they were studied in.