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Peptides after CCL or TPLO surgery in dogs
Eight to twelve weeks of restricted activity after a cruciate repair is where owners look for anything that helps. Here is what they use, and the one rule: the surgeon knows.
First, your vet
The surgeon’s discharge plan: rest, controlled leash walks, the recheck radiographs. A peptide protocol is added to that plan, with the surgeon told, not slipped in beside it.
What owners use
The Post-Op Recovery bundle: REPAIR for the soft tissue around the repair, with VITAL for the dog losing condition on crate rest. Start when the incision has healed, run eight weeks, dose by band.
Canitide products are sold for research purposes and are not FDA-approved drugs. Talk to your veterinarian before starting any protocol, and bring the dosing card.
Canitide REPAIR
BPC-157 10 mg + TB-500 10 mg · 5 days on / 2 days off · 8-week cycle, then 4 weeks off
Post-Op Recovery
Eight weeks of support after orthopedic surgery, with your surgeon's sign-off.
- REPAIR cartridge ×2
- GUT capsules
What the research is
The 2003 rat Achilles tendon study and the 2011 tendon fibroblast work are the reason BPC-157 is used around orthopedic surgery. No study has been done in dogs after CCL repair.
Primary sources only, each labeled with the model it was studied in.
- rat tendonStable gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendonStaresinic M et al. · J Orthop Res 2003
- rat tendon fibroblastsThe promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migrationChang CH et al. · J Appl Physiol 2011
- reviewBrain-gut axis and pentadecapeptide BPC 157: theoretical and practical implicationsSikiric P et al. · Curr Neuropharmacol 2016
- reviewThymosin β4: actin-sequestering protein moonlights to repair injured tissuesGoldstein AL, Hannappel E, Kleinman HK · Trends Mol Med 2005
- mouseThymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repairBock-Marquette I et al. · Nature 2004
- dogs (epidemiology)Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogsEnomoto M et al. · Sci Rep 2024
Questions
Will it speed up the bone healing after TPLO?
The research is on tendon, ligament and muscle, not bone. Nobody has shown faster osteotomy healing with any peptide, and the recheck radiographs are what tell you the bone is healed.
Both knees?
About half of dogs eventually tear the other side. Owners often continue REPAIR as maintenance cycles after recovery; ask your surgeon.
Dosage charts: BPC-157 for dogs · TB-500 for dogs · calculator