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Dosing / BPC-157

Dosing by peptide

BPC-157 for dogs: dosage chart by weight

BPC-157 is a fifteen-amino-acid peptide derived from a protein in gastric juice. It has three decades of rodent research on tendon, ligament, muscle and gut healing, and a 2022 pharmacokinetic study in beagles. It is the most-used peptide in dogs by a wide margin.

Canitide REPAIR · 5 days on / 2 days off · 8-week cycle, then 4 weeks off

BPC-157 dose by weight band.

One pen unit is 0.01 mL and carries about 33 mcg of BPC-157. The bands are set from the mg/kg ranges in the animal research, rounded to whole units.

Weight bandPer dosePer dose (mcg)Per weekCartridge lastsClub cadence
Small (under 20 lb)6 units198 mcg30 units~10 weeksevery 8 weeks
Medium (20–50 lb)9 units297 mcg45 units~6 weeksevery 6 weeks
Large (50–90 lb)12 units396 mcg60 units~5 weeksevery 4 weeks
Giant (90 lb and up)15 units495 mcg75 units~4 weeksevery 4 weeks

Cartridges hold 300 usable units after the 2-unit prime. Missed a dose? Skip it and continue; never double up.

Download this chart (PDF) ↓

Canitide products are sold for research purposes and are not FDA-approved drugs. Talk to your veterinarian before starting any protocol, and bring the dosing card.

Your dog

Enter a weight, get the number.

Owners reach for it when a dog is slowing down with age, recovering from soft-tissue injury or orthopedic surgery, or struggling with a stubborn gut. In Canitide it is paired with TB-500 in REPAIR, and taken by mouth in its arginate salt in GUT.

Reserve Canitide REPAIR
lb

If you use a vial

A 10 mg vial of BPC-157 reconstituted in 3 mL of bacteriostatic water is 3.33 mg/mL, the same concentration as a REPAIR cartridge, so the unit numbers below read the same on a U-100 insulin syringe. On a U-100 insulin syringe one unit is also 0.01 mL, so the chart above reads the same. What changes with the pen: no reconstitution, no drawing up, a sterility-tested cartridge, a 32G × 4 mm needle, and a dial you cannot misread. The pen versus vial kits.

Questions about BPC-157 for dogs

How much BPC-157 do I give a dog?

Canitide doses REPAIR by weight band: 6 units a dose under 20 lb, 9 units at 20–50 lb, 12 units at 50–90 lb and 15 units at 90 lb and up, five days a week for eight weeks. One unit is 0.01 mL and carries about 33 mcg of BPC-157, so a medium dog gets about 300 mcg a dose. The bands are set from the mg/kg ranges in the animal research; bring the card to your vet.

Is oral BPC-157 for dogs any good?

BPC-157 was first studied for gastric and intestinal protection, which is why an oral form is credible for gut use. Canitide GUT uses the stable arginate salt in a delayed-release capsule, opened over food or given whole. For joints and tendons, owners use the injectable form.

Where do I inject BPC-157 in a dog?

Under loose skin at the scruff or flank, the way insulin is given. With the Canitide Pen you twist on a 32G × 4 mm needle, dial the units and press for five seconds. Most dogs react less than they do to a vaccine.

Is BPC-157 safe for dogs?

No controlled canine trial has been completed, so nobody can honestly say "safe". In the animal research the most common findings are mild and local: a small bump at the injection site and a day or two of lethargy. Talk to your vet before starting, especially for dogs on NSAIDs, steroids or insulin, and never for dogs with cancer without an oncologist’s sign-off.

The research

Primary sources only, each labeled with the model it was studied in.

  • rat tendonStable gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendonStaresinic M et al. · J Orthop Res 2003
  • rat tendon fibroblastsThe promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migrationChang CH et al. · J Appl Physiol 2011
  • reviewBrain-gut axis and pentadecapeptide BPC 157: theoretical and practical implicationsSikiric P et al. · Curr Neuropharmacol 2016
  • reviewThymosin β4: actin-sequestering protein moonlights to repair injured tissuesGoldstein AL, Hannappel E, Kleinman HK · Trends Mol Med 2005
  • mouseThymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repairBock-Marquette I et al. · Nature 2004
  • dogs (epidemiology)Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogsEnomoto M et al. · Sci Rep 2024
All sources

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